How it Works
Ethanol, the molecule present in various alcoholic beverages, exerts its toxicological effects both directly and indirectly, via oxidation to a metabolite, acetaldehyde. This conversion/oxidation of ethanol to acetaldehyde occurs via alcohol dehydrogenase. Once acetaldehyde is formed, it is further oxidized by yet another enzyme, acetaldehyde dehydrogenase, into acetic acid.
Because much of the toxicity associated with ethanol ingestion is caused by acetaldehyde, utilizing a formulation which can effectively increase oxidation acetaldehyde, could potentially reduce the toxicity normally seen.
A Human clinical study using a key ingredient in Neutralize was given to a group of men, 1 hour before and 1 hour after ethanol ingestion, was able to significantly reduce acetaldehyde concentrations at 1, 2 and 3 hours post-ingestion, compared to control. At 1 hour, acetaldehyde levels were approximately 100% lower relative to control.
In another Human Clinical study, humans administered a key ingredient in Neutralize, 1 hour before and 1 hour after ethanol ingestion, demonstrated a reduction of acetaldehyde levels by approximately 1/3rd . Taurine is known to be a potent inducer of acetaldehyde dehydrogenase activity.
Interestingly, in animal models, data indicate that both ethanol and acetaldehyde are responsible for decreased protein synthesis in skeletal muscle. Thus, it may also be possible that a supplement containing these ingredients and reduce ethanol and acetaldehyde concentrations after alcohol ingestion, may mitigate the harmful effects of alcohol upon muscle.